Prkg1^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Prkg1^tm1.1Arte
• Name: protein kinase, cGMP-dependent, type I; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5313455
• Synonyms: PKG 1alpha Cys42Ser KI, PKG 1alpha KI
• Gene: Prkg1 Location: Chr19:30541889-31742433 bp, - strand Genetic Position: Chr19, 25.17 cM, cytoband C2
• Alliance: Prkg1^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181180
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A point mutation was introduced into exon 1a causing the cysteine encoded by codon 43 to be replaced by serine (C43S). An FRT-flanked neomycin selection cassette was inserted 593 bp downstream. The selection cassette was subsequently removed by crossing to mice expressing flp recombinase. (J:181180)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkg1 Mutation: 65 strains or lines available

References

• Original: J:181180 Prysyazhna O, et al., Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension. Nat Med. 2012;18(2):286-90
• All: 10 reference(s)