Treml4^tm1Ji
Targeted Allele Detail

Summary

• Symbol: Treml4^tm1Ji
• Name: triggering receptor expressed on myeloid cells-like 4; targeted mutation 1, Juliana Idoyaga
• MGI ID: MGI:5313376
• Gene: Treml4 Location: Chr17:48571323-48582388 bp, + strand Genetic Position: Chr17, 23.99 cM
• Alliance: Treml4^tm1Ji page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180744
• Parent Cell Line: CY2.4 (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.7 kb fragment including exons 1 and 2 was replaced with a floxed cassette containing a neomycin resistance gene under the control of the RNA polymerase II promoter and cre recombinase under the control of the angiotensin converting enzyme promoter. Cre mediated recombination during spermatogenesis removed the selection cassette. (J:180744)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Treml4 Mutation: 17 strains or lines available

References

• Original: J:180744 Hemmi H, et al., Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein. J Immunol. 2012 Feb 1;188(3):1147-55
• All: 2 reference(s)