Rb1^tm1Htr
Targeted Allele Detail

Summary

• Symbol: Rb1^tm1Htr
• Name: RB transcriptional corepressor 1; targeted mutation 1, Hein te Riele
• MGI ID: MGI:5312884
• Synonyms: Rb^N750F
• Gene: Rb1 Location: Chr14:73430298-73563446 bp, - strand Genetic Position: Chr14, 38.73 cM, cytoband D3
• Alliance: Rb1^tm1Htr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118264
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: Oligonucleotide targeting produced a nucleotide substitution (TAAC to CTTT) in exon 22 that results in an amino acid substitution of phenylalanine for asparagine at position 750 (N750F). (J:118264)

Tumor Data

List all tumor models in MMHCdb carrying Rb1^tm1Htr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rb1 Mutation: 116 strains or lines available

Notes

Originally generated in ES cells containing Msh2^tm1Htr.

References

• Original: J:118264 Aarts M, et al., Generation of a mouse mutant by oligonucleotide-mediated gene modification in ES cells. Nucleic Acids Res. 2006;34(21):e147
• All: 2 reference(s)