Defb14^tm1Wme
Targeted Allele Detail

Summary

• Symbol: Defb14^tm1Wme
• Name: defensin beta 14; targeted mutation 1, Werner Mueller
• MGI ID: MGI:5312881
• Gene: Defb14 Location: Chr8:19244373-19245228 bp, + strand Genetic Position: Chr8, 10.35 cM
• Alliance: Defb14^tm1Wme page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180788
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Oligonucleotide targeting inserted 4 bp (AATA) into exon 2. The insertion resulted in a stop codon and a frameshift mutation. (J:180788)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Defb14 Mutation: 4 strains or lines available

Notes

Originally generated in ES cells containing Msh3^tm1Htr.

References

• Original: J:180788 Navid F, et al., Induction of regulatory T cells by a murine beta-defensin. J Immunol. 2012 Jan 15;188(2):735-43
• All: 2 reference(s)