Tg(H2-Ea-LACK)1Ngkh
Transgene Detail

Summary

• Symbol: Tg(H2-Ea-LACK)1Ngkh
• Name: transgene insertion 1, Nicolas Glaichenhaus
• MGI ID: MGI:5311331
• Synonyms: IE-LACK
• Transgene: Tg(H2-Ea-LACK)1Ngkh Location: unknown
• Alliance: Tg(H2-Ea-LACK)1Ngkh page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A truncated cDNA encoding the Leishmania major activated protein kinase C receptor (LACK) with an N-terminal hemagglutinin (HA) epitope was placed under control of the promoter of the mouse MHC type II I-Ealpha promoter (k allele). LACK transcripts are detected in primary and secondary lymphoid organs, including thymus, spleen and bone marrow, but not in liver, kidney or muscle of transgenic mice. (J:181384)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:181384 Julia V, et al., Resistance to Leishmania major induced by tolerance to a single antigen. Science. 1996 Oct 18;274(5286):421-3
• All: 2 reference(s)