Tg(Fabp2-CFTR*)1Wsh
Transgene Detail

Summary

• Symbol: Tg(Fabp2-CFTR*)1Wsh
• Name: transgene insertion 1, Michael J Welsh
• MGI ID: MGI:5308021
• Synonyms: CFTRdeltaR
• Transgene: Tg(Fabp2-CFTR*)1Wsh Location: unknown
• Alliance: Tg(Fabp2-CFTR*)1Wsh page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL/J)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Fabp2-CFTR*)1Wsh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CFTR (1080)

  Cftr	(MGI:88388)

• Mutation details: Nucleotides -1178 to +28 of the rat intestinal fatty acid binding protein (Fabp2) promoter drive expression of a human CFTR cDNA from which sequences encoding N-terminal residues 708-759 have been deleted. Line 1 was generated. (J:169220)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:169220 Ostedgaard LS, et al., Cystic fibrosis transmembrane conductance regulator with a shortened R domain rescues the intestinal phenotype of CFTR-/- mice. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2921-6
• All: 1 reference(s)