Slc4a5^tm1Boet
Targeted Allele Detail

Summary

• Symbol: Slc4a5^tm1Boet
• Name: solute carrier family 4, sodium bicarbonate cotransporter, member 5; targeted mutation 1, Thomas Boettger
• MGI ID: MGI:5306979
• Synonyms: Slc4a5^lox
• Gene: Slc4a5 Location: Chr6:83196810-83281927 bp, + strand Genetic Position: Chr6, 35.94 cM
• Alliance: Slc4a5^tm1Boet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180608
• Parent Cell Line: MPI-II (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 7. A floxed neo cassette was inserted downstream of exon 7. (J:180608)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc4a5 Mutation: 49 strains or lines available

References

• Original: J:180608 Groger N, et al., Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis. Hum Mol Genet. 2012 Mar 1;21(5):1025-36
• All: 1 reference(s)