Tg(Alb-FKBP12/CASP8)#Lsu
Transgene Detail

Summary

• Symbol: Tg(Alb-FKBP12/CASP8)#Lsu
• Name: transgene insertion, Lishan Su
• MGI ID: MGI:5306232
• Transgene: Tg(Alb-FKBP12/CASP8)#Lsu Location: unknown
• Alliance: Tg(Alb-FKBP12/CASP8)#Lsu page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb-FKBP12/CASP8)#Lsu expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CASP8 (841)

  Casp8

  (MGI:1261423)

  Transgene codes for a fusion protein of human FKBP1A and CASP8.

  human

  FKBP1A (2280)

  Fkbp1a

  (MGI:95541)

  Transgene codes for a fusion protein of human FKBP1A and CASP8.

• Mutation details: This transgene is comprised of the murine albumin reporter driving expression of a fusion protein of the human FK506 binding protein 1A and human caspase 8 from Ser217-Asp479. Ligand induced dimerization results in activation of caspase 8 and ablation of hepatocytes expressing this transgene. (J:180276)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:180276 Washburn ML, et al., A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease. Gastroenterology. 2011 Apr;140(4):1334-44
• All: 1 reference(s)