Tg(Thy1-MAPT*)3610Gds
Transgene Detail

Summary

• Symbol: Tg(Thy1-MAPT*)3610Gds
• Name: transgene insertion 3610, Gerard Schellenberg
• MGI ID: MGI:5305849
• Synonyms: E391-3610, THY1.2::TauE391
• Transgene: Tg(Thy1-MAPT*)3610Gds Location: unknown
• Alliance: Tg(Thy1-MAPT*)3610Gds page

Transgene origin

• Strain of Origin: C57BL/6 x C3H

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-MAPT*)3610Gds expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: The transgenic construct contains the 4R1N tau isoform truncated at amino acid position E391(glutamic acid) and under the direction of the Thy1b (Thy1.2) neuron specific promoter. The construct contains sequences encoded by alternatively spliced exons 2 and 10 and has 4 microtubule repeats. Lines 3608 and 3610 was generated. (J:179578)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:179578 McMillan PJ, et al., Truncation of tau at E391 promotes early pathologic changes in transgenic mice. J Neuropathol Exp Neurol. 2011 Nov;70(11):1006-19
• All: 1 reference(s)