Tg(H2-D^d/H2-L^d)DL1Ul
Transgene Detail

Summary

• Symbol: Tg(H2-D^d/H2-L^d)DL1Ul
• Name: transgene insertion DL1, Urban Lendahl
• MGI ID: MGI:5305234
• Synonyms: DL1, T62UL, Tg(H2D^d alfa1/H2D^d alfa2/H2D^d alfa3)DL1
• Transgene: Tg(H2-D^d/H2-L^d)DL1Ul Location: unknown
• Alliance: Tg(H2-D^d/H2-L^d)DL1Ul page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-D^d/H2-L^d)DL1Ul expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	H2-D (MGI:1933561)	Transgene codes for a fusion protein of H2-D and H2-L.
  mouse	H2-L (MGI:95912)	Transgene codes for a fusion protein of H2-D and H2-L.

• Mutation details: This transgene contains mouse genomic DNA encoding a chimeric major histocompatibility type I (MHC1) molecule comprising the alpha1 and alpha2 domains of the H2-D^d molecule joined to the alpha3, transmembrane and cytoplasmic domains of H2-L^d. (J:180044)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:180044 Sentman CL, et al., H-2 allele-specific protection from NK cell lysis in vitro for lymphoblasts but not tumor targets. Protection mediated by alpha 1/alpha 2 domains. J Immunol. 1994 Dec 15;153(12):5482-90
• All: 2 reference(s)