Ube3a^tm2.1Alb
Targeted Allele Detail

Summary

• Symbol: Ube3a^tm2.1Alb
• Name: ubiquitin protein ligase E3A; targeted mutation 2.1, Arthur L Beaudet
• MGI ID: MGI:5302232
• Gene: Ube3a Location: Chr7:58878498-58961284 bp, + strand Genetic Position: Chr7, 33.95 cM
• Alliance: Ube3a^tm2.1Alb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130068
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: Yellow fluorescent protein (YFP) and a floxed neomycin cassette were fused to exon 10. Cre-mediated recombination removed the neo cassette. Expression of YFP is through inheritance of the maternal allele and recapitulates endogenous expression. (J:130068)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ube3a Mutation: 73 strains or lines available

References

• Original: J:130068 Dindot SV, et al., The Angelman syndrome ubiquitin ligase localizes to the synapse and nucleus, and maternal deficiency results in abnormal dendritic spine morphology. Hum Mol Genet. 2008 Jan 1;17(1):111-8
• All: 6 reference(s)