Tg(Kcne1-cre/ERT2)1Imos
Transgene Detail

Summary

• Symbol: Tg(Kcne1-cre/ERT2)1Imos
• Name: transgene insertion 1, Ivan P Moskowitz
• MGI ID: MGI:5301931
• Synonyms: minK:CreER^T2
• Transgene: Tg(Kcne1-cre/ERT2)1Imos Location: unknown
• Alliance: Tg(Kcne1-cre/ERT2)1Imos page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Kcne1-cre/ERT2)1Imos expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Kcne1 (MGI:96673)

• Mutation details: The transgene construct was generated by BAC recombineering methods in bacteria. The Kcne1 (minK) coding sequence in BAC RP23276-120 was replaced with a cre/ERT2-bGH pA-Frt-Zeo-Frt cassette. The purified BAC was microinjected into fertilized CD-1 oocytes. Four founder lines that exhibited consisted inducible cre activity in the cardiac conduction were obtained. One line was analyzed in greater detail. Line numbers are not available. (J:178662)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Kcne1 (mouse) Summary of all recombinase alleles driven by Kcne1. Comparative matrix view of recombinase activities Alliance mouse Kcne1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:178662 Arnolds DE, et al., Inducible recombination in the cardiac conduction system of minK: CreERT(2) BAC transgenic mice. Genesis. 2011 Nov;49(11):878-84
• All: 4 reference(s)