Dock1^tm1.1Ysfk
Targeted Allele Detail

Summary

• Symbol: Dock1^tm1.1Ysfk
• Name: dedicator of cytokinesis 1; targeted mutation 1.1, Yoshinori Fukui
• MGI ID: MGI:5301316
• Synonyms: Dock180^d
• Gene: Dock1 Location: Chr7:134272416-134775376 bp, + strand Genetic Position: Chr7, 79.14 cM
• Alliance: Dock1^tm1.1Ysfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178190
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted
• Mutation: Intragenic deletion
• Mutation details: One loxP site was inserted upstream of exon 2 (containing the SH3 domain) and a floxed neomycin resistance cassette was inserted downstream. Mice were bred to Tg(EIIa-cre)C5379Lmgd expressing mice to excise exon 2 and the selection cassette. Normal transcription is observed on Northern blots but protein levels are less than 10% of levels in control mice. (J:178190)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dock1 Mutation: 129 strains or lines available

References

• Original: J:178190 Sanematsu F, et al., DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4. Circ Res. 2010 Oct 29;107(9):1102-5
• All: 1 reference(s)