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Transgene Detail
Symbol: Tg(MMTV-tTA)25754Kuw
Name: transgene insertion 25754, Kay-Uwe Wagner
MGI ID: MGI:5300554
Synonyms: MMTV-tTA
Transgene: Tg(MMTV-tTA)25754Kuw  Location: unknown  Genetic Position: Chr8, Syntenic
Alliance: Tg(MMTV-tTA)25754Kuw page
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Transactivator)
Mutation:    Insertion
Mutation detailsThe mouse mammary gland tumor virus (MMTV) promoter drives mammary gland-specific expression of a tetracycline transactivator (tTA). Two lines were generated (25754 and 25755). Line 25754 integrated on chromosome 8 (chr8:12,485,790-12,564,686; mouse mm10), approximately 10kb upstream of the Spaca7 locus. Currently there are no genes annotated in the integration region. This analysis also identified the transgene includes an SV40 NLS and polyA signal. (J:178842)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:178842 Zhang Q, et al., Cyclin D3 Compensates for the Loss of Cyclin D1 during ErbB2-Induced Mammary Tumor Initiation and Progression. Cancer Res. 2011 Dec 15;71(24):7513-24
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory