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Targeted Allele Detail
Symbol: Oxsr1tm1.2Ssy
Name: oxidative-stress responsive 1; targeted mutation 1.2, Sung-Sen Yeh
MGI ID: MGI:5297492
Synonyms: OSR1-
Gene: Oxsr1  Location: Chr9:119067498-119151493 bp, - strand  Genetic Position: Chr9, 71.33 cM
Alliance: Oxsr1tm1.2Ssy page
Germline Transmission:  Earliest citation of germline transmission: J:177443
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 9 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 10 via homologous recombination. Flp and cre mediated recombination removed the neo cassette and exons 9 and 10. (J:177443)
Generation of the Oxsr1tm1.1Ssy and Oxsr1tm1.2Ssy alleles
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oxsr1 Mutation:  41 strains or lines available
Original:  J:177443 Lin SH, et al., Impaired phosphorylation of Na+-K+-2Cl- cotransporter by oxidative stress-responsive kinase-1 deficiency manifests hypotension and Bartter-like syndrome. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17538-43
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory