b2b134Clo
Chemically induced Allele Detail

Summary

• Symbol: b2b134Clo
• Name: Mutant line 134; Bench to Bassinet Program (B2B/CVDC), mutation 134 Cecilia Lo
• MGI ID: MGI:5297417
• Gene: b2b134Clo Location: unknown
• Alliance: b2b134Clo page

EFIC imaging reveals DORV, hypoplastic pulmonary artery (PA), coronary fistula and VSD.

Show the 8 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: B2B/CvDC

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• This ENU-induced mutation was isolated in a screen at the University of Pittsburgh.

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any b2b134Clo Mutation: 1 strain or line available

Notes

Summative Diagnosis
Cardiovascular defects: Double outlet right ventricle (DORV), pulmonary stenosis (hypoplastic pulmonary artery), hypoplastic transverse arch, and coronary artery fistula.
Non-cardiovascular defects: Hydronephrosis, kidney cysts
Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID	Code Description
0600	Double outlet right ventricle
0602	DORV, ventricular defect committed to aorta
1610	Pulmonary stenosis
2240	Coronary arterio-venous fistula
2704	Aortic arch hypoplasia
2966	Hypoplastic main pulmonary artery
3804	Congenital heart disease
3950	{S,D,D}
4502	Hydronephrosis
4508	Polycystic kidney disease

References

• Original: J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-09-12
• All: 2 reference(s)