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Snap25tm1Mtaka
Targeted Allele Detail
Summary
Symbol: Snap25tm1Mtaka
Name: synaptosomal-associated protein 25; targeted mutation 1, Masami Takahashi
MGI ID: MGI:5297219
Synonyms: Snap25S187A
Gene: Snap25  Location: Chr2:136555373-136624348 bp, + strand  Genetic Position: Chr2, 67.56 cM
Alliance: Snap25tm1Mtaka page
Abnormal locomotor activity in open field in Snap25tm1Mtaka/Snap25tm1Mtaka mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177870
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA minigene containing a cDNA with nucleotide substitution(s) that results in the amino acid substitution of alanine for serine at position 187 (S187A) and a neo cassette were inserted into exon 7. (J:177870)
Generation of the Snap25tm1Mtaka allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Snap25 Mutation:  26 strains or lines available
References
Original:  J:177870 Kataoka M, et al., A single amino acid mutation in SNAP-25 induces anxiety-related behavior in mouse. PLoS One. 2011;6(9):e25158
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory