Itgb1tm9.1Ref
Targeted Allele Detail
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Symbol: |
Itgb1tm9.1Ref |
Name: |
integrin beta 1 (fibronectin receptor beta); targeted mutation 9.1, Reinhard Fassler |
MGI ID: |
MGI:5296844 |
Synonyms: |
Y783F |
Gene: |
Itgb1 Location: Chr8:129412135-129459681 bp, + strand Genetic Position: Chr8, 76.09 cM, cytoband E2
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Alliance: |
Itgb1tm9.1Ref page
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Normal appearance of Itgb1tm9.1Ref/Itgb1tm9.1Ref mice
Show the 1 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Not Specified) |
Mutations: |
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Insertion, Single point mutation
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Mutation details: A floxed neo cassette was inserted downstream of a modified exon 16 in which nucleotide substitution results in the amino acid substitution of phenylalanine for tyrosine at position 783 (Y783F). Cre-mediated recombination removed the neo cassette.
(J:177979)
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Targeting strategy for introducing point mutations in the cytoplasmic domain of Itgb1 |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Itgb1 Mutation: |
59 strains or lines available
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Original: |
J:177979 Czuchra A, et al., Genetic analysis of beta1 integrin "activation motifs" in mice. J Cell Biol. 2006 Sep 11;174(6):889-99 |
All: |
2 reference(s) |
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