Glis3^tm1.1Chan
Targeted Allele Detail

Summary

• Symbol: Glis3^tm1.1Chan
• Name: GLIS family zinc finger 3; targeted mutation 1.1, Lawrence Chan
• MGI ID: MGI:5296612
• Synonyms: Glis3^fl
• Gene: Glis3 Location: Chr19:28236251-28657477 bp, - strand Genetic Position: Chr19, 22.88 cM
• Alliance: Glis3^tm1.1Chan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177082
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette. (J:177082)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glis3 Mutation: 40 strains or lines available

References

• Original: J:177082 Yang Y, et al., The Kruppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice. Diabetologia. 2011 Oct;54(10):2595-605
• All: 3 reference(s)