Dll4^tm1Vlcg
Targeted Allele Detail

Summary

• Symbol: Dll4^tm1Vlcg
• Name: delta like canonical Notch ligand 4; targeted mutation 1, Velocigene
• MGI ID: MGI:5295263
• Synonyms: humanized Dll4
• Gene: Dll4 Location: Chr2:119156265-119166147 bp, + strand Genetic Position: Chr2, 59.97 cM, cytoband E3
• Alliance: Dll4^tm1Vlcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177290
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The murine gene is replaced with the entire region of the gene that encodes the extracellular portion of the protein with the equivalent region of the human Dll4 gene from the start codon to the beginning of the transmembrane region (7 kb genomic DNA). (J:177290)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dll4 Mutation: 26 strains or lines available

References

• Original: J:177290 Billiard F, et al., Ongoing Dll4-Notch signaling is required for T-cell homeostasis in the adult thymus. Eur J Immunol. 2011 Aug;41(8):2207-16
• All: 2 reference(s)