L1cam^tm1.1Pfm
Targeted Allele Detail

Summary

• Symbol: L1cam^tm1.1Pfm
• Name: L1 cell adhesion molecule; targeted mutation 1.1, Patricia F Maness
• MGI ID: MGI:5295191
• Synonyms: L1(Y1229H)
• Gene: L1cam Location: ChrX:72897384-72924843 bp, - strand Genetic Position: ChrX, 37.43 cM, cytoband A6-B
• Alliance: L1cam^tm1.1Pfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131051
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A floxed neo cassette was inserted into intron 27. Exon 28 was replaced with a modified exon 28 in wich nucleotide substitution results in the amino acid substitution of histidine for tyrosine at position 1229 (Y1229H) in the ankyrin-binding site (FIGQY1229). Cre-mediated recombination removed the neo cassette. (J:131051)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any L1cam Mutation: 12 strains or lines available

References

• Original: J:131051 Buhusi M, et al., L1 interaction with ankyrin regulates mediolateral topography in the retinocollicular projection. J Neurosci. 2008 Jan 2;28(1):177-88
• All: 5 reference(s)