Tg(Myh6/tetO-ATP2B4)1Jmol
Transgene Detail

Summary

• Symbol: Tg(Myh6/tetO-ATP2B4)1Jmol
• Name: transgene insertion 1, Jeffery D Molkentin
• MGI ID: MGI:5294558
• Transgene: Tg(Myh6/tetO-ATP2B4)1Jmol Location: unknown
• Alliance: Tg(Myh6/tetO-ATP2B4)1Jmol page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Myh6/tetO-ATP2B4)1Jmol expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ATP2B4 (493)

  Atp2b4

  (MGI:88111)

• Mutation details: Human ATP2B4 cDNA (also known as PMCA4b) and a tetracycline-responsive promoter element (tetO) were fused to the cardiac-specific alpha myosin heavy chain (Myh6) mouse promoter. Line 1 was generated. (J:149624)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:149624 Wu X, et al., Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents. J Clin Invest. 2009 Apr;119(4):976-85
• All: 1 reference(s)