Tg(CEPHY141G6)28Hgc
Transgene Detail

Summary

• Symbol: Tg(CEPHY141G6)28Hgc
• Name: transgene insertion 28, Edward M Rubin
• MGI ID: MGI:5293437
• Synonyms: Tg(YAC141G6)28Hgc, YAC 141G6, YAC 141G6 Line 28, YAC Lg 28
• Transgene: Tg(CEPHY141G6)28Hgc Location: unknown
• Alliance: Tg(CEPHY141G6)28Hgc page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CEPHY141G6)28Hgc expresses 4 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HLCS (3141)

  Hlcs	(MGI:894646)

  human

  PIGP (51227)

  Pigp	(MGI:1860433)

  human

  TTC3 (7267)

  Ttc3	(MGI:1276539)

  human

  VPS26C (10311)

  Vps26c

  (MGI:1206040)

• Mutation details: The transgene comprises a yeast artificial chromosome (YAC) from the CEPH Whole Genome MegaYAC Library carrying a 475-kb fragment of DNA from human Chromosome 21 containing the genes HLCS (holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)), PIGP (phosphatidylinositol glycan anchor biosynthesis, class P; formerly DSCR5), TTC3 (tetratricopeptide repeat domain 3) and DSCR3 (Down syndrome critical region gene 3). This transgenic line was shown by quantitative PCR analysis to bear three copies of the YAC. (J:128897)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:128897 Smith DJ, et al., Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2. Genomics. 1995 Jun 10;27(3):425-34
• All: 6 reference(s)