Gprc5b^tm1Yhir
Targeted Allele Detail

Summary

• Symbol: Gprc5b^tm1Yhir
• Name: G protein-coupled receptor, family C, group 5, member B; targeted mutation 1, Yoshio Hirabayashi
• MGI ID: MGI:5293387
• Gene: Gprc5b Location: Chr7:118571270-118594434 bp, - strand Genetic Position: Chr7, 63.72 cM, cytoband F3
• Alliance: Gprc5b^tm1Yhir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176063
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with lacZ and neo cassettes via homologous recombination. LacZ expression recapitulates endogenous gene expression. (J:176063)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gprc5b Mutation: 28 strains or lines available

References

• Original: J:176063 Sano T, et al., Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice. Biochem Biophys Res Commun. 2011 Sep 2;412(3):460-5
• All: 3 reference(s)