Fstl1^{tm2.1(cre/ERT2)Mvdh}
Targeted Allele Detail

Summary

• Symbol: Fstl1^{tm2.1(cre/ERT2)Mvdh}
• Name: follistatin-like 1; targeted mutation 2.1, Maurice JB van den Hoff
• MGI ID: MGI:5293378
• Synonyms: Fstl1^G, Fstl1^{tm2.1(EGFP,cre/ERT2)Mvdh}
• Gene: Fstl1 Location: Chr16:37597417-37656878 bp, + strand Genetic Position: Chr16, 26.48 cM
• Alliance: Fstl1^{tm2.1(cre/ERT2)Mvdh} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176532
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Fstl1^{tm2.1(cre/ERT2)Mvdh} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Fstl1 (MGI:102793)

• Mutation details: An EGFP-IRES-cre/ERT2 cassette and a neo selection marker were inserted into the ATG initiation codon of Fstl1. Chimeras were bred to B6 females and the offspring were crossed to PGK-cre mice to delete the neo marker. (J:176532)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Fstl1 (mouse) Summary of all recombinase alleles driven by Fstl1. Alliance mouse Fstl1 gene page

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fstl1 Mutation: 44 strains or lines available

References

• Original: J:176532 Sylva M, et al., The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis. PLoS One. 2011;6(8):e22616
• All: 2 reference(s)