Gss^tm1Wink
Targeted Allele Detail

Summary

• Symbol: Gss^tm1Wink
• Name: glutathione synthetase; targeted mutation 1, Andreas Winkler
• MGI ID: MGI:5287683
• Gene: Gss Location: Chr2:155405101-155434730 bp, - strand Genetic Position: Chr2, 77.26 cM
• Alliance: Gss^tm1Wink page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175759
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4.3 kb genomic fragment including exons 9 - 11 was replaced with a neo cassette via homologous recombination. Western blot analysis indicated about a 50% reduction in protein expression in various tissues from heterozygous mice. (J:175759)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gss Mutation: 35 strains or lines available

References

• Original: J:175759 Winkler A, et al., Glutathione is essential for early embryogenesis - Analysis of a glutathione synthetase knockout mouse. Biochem Biophys Res Commun. 2011 Aug 19;412(1):121-6
• All: 1 reference(s)