Hoxa1^tm8.1Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxa1^tm8.1Mrc
• Name: homeobox A1; targeted mutation 8.1, Mario R Capecchi
• MGI ID: MGI:5287661
• Synonyms: Hoxa1^c
• Gene: Hoxa1 Location: Chr6:52132573-52135299 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa1^tm8.1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175781
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and EcoRI siter were inserted 200 bp upstream of the transcription initiation site and a loxP site, EcoRI site, and FRT flanked neo cassette were inserted36 bp downstream of the stop codon via homologous recombination. Flp mediated recombination removed the neo cassette. (J:175781)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa1 Mutation: 15 strains or lines available

References

• Original: J:175781 Makki N, et al., Identification of novel Hoxa1 downstream targets regulating hindbrain, neural crest and inner ear development. Dev Biol. 2011 Sep 15;357(2):295-304
• All: 1 reference(s)