Tg(CMV-KRAS*G12V,-EGFP)#Mjar
Transgene Detail

Summary

• Symbol: Tg(CMV-KRAS*G12V,-EGFP)#Mjar
• Name: transgene insertion, MJ Arends
• MGI ID: MGI:5286106
• Synonyms: K-ras^V12
• Transgene: Tg(CMV-KRAS*G12V,-EGFP)#Mjar Location: unknown
• Alliance: Tg(CMV-KRAS*G12V,-EGFP)#Mjar page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: A CMV promoter drives ubiquitous expression of a human KRAS minigene with a nucleotide substitution that results in the amino acid substitution of valine for glycine at position 12, an IRES, and EGFP. The minigene is preceded by a floxed neo cassette. Cre-mediated recombination is required to allow for expression of the Kras mutation that occurs in 40-50% of human colorectal adenomas and carcinomas. (J:122904)

Tumor Data

List all tumor models in MMHCdb carrying Tg(CMV-KRAS*G12V,-EGFP)#Mjar

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:122904 Luo F, et al., Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice. Oncogene. 2007 Jun 28;26(30):4415-27
• All: 4 reference(s)