Slc39a8tm1.1Dwn
Targeted Allele Detail
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Symbol: |
Slc39a8tm1.1Dwn |
Name: |
solute carrier family 39 (metal ion transporter), member 8; targeted mutation 1.1, Daniel W Nebert |
MGI ID: |
MGI:5285694 |
Gene: |
Slc39a8 Location: Chr3:135531040-135594333 bp, + strand Genetic Position: Chr3, 63.04 cM
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Alliance: |
Slc39a8tm1.1Dwn page
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Germline Transmission: |
Earliest citation of germline transmission:
J:174970
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted 316bp downstream of exon 6 in intron 6. A loxP and Frt flanked neomycin selection cassette were inserted in intron 3. The neo selection cassette was subsequently removed by crossing to mice expressing flp recombinase. This left exons 4, 5, and 6 flanked by loxP sites. However, cre recombinase failed to excise the floxed exons in living mice although excision succeeded in cultured cells.
(J:174970)
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Original: |
J:174970 Wang B, et al., Generation of a Slc39a8 hypomorph mouse: markedly decreased ZIP8 Zn(2)/(HCO) transporter expression. Biochem Biophys Res Commun. 2011 Jul 1;410(2):289-94 |
All: |
2 reference(s) |
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