Gna12^tm1.1Cgh
Targeted Allele Detail

Summary

• Symbol: Gna12^tm1.1Cgh
• Name: guanine nucleotide binding protein, alpha 12; targeted mutation 1.1, Shaun R Coughlin
• MGI ID: MGI:5140818
• Synonyms: Gna12-lacZ
• Gene: Gna12 Location: Chr5:140745699-140816186 bp, - strand Genetic Position: Chr5, 79.3 cM
• Alliance: Gna12^tm1.1Cgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174313
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: LacZ with an SV40 polyadenylation sequence and a floxed neo cassette were inserted inframe with the first coding 51 base pairs of exon 1. Cre-mediated recombination removed the neo cassette. (J:174313)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gna12 Mutation: 21 strains or lines available

References

• Original: J:174313 Green JA, et al., The sphingosine 1-phosphate receptor S1P maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol. 2011;12(7):672-80
• All: 1 reference(s)