Vapb^{Gt(OST284921)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Vapb^{Gt(OST284921)Lex}
• Name: vesicle-associated membrane protein, associated protein B and C; gene trap OST284921, Lexicon Genetics
• MGI ID: MGI:5085882
• Gene: Vapb Location: Chr2:173579378-173626132 bp, + strand Genetic Position: Chr2, 97.37 cM, cytoband H3
• Alliance: Vapb^{Gt(OST284921)Lex} page

Mutation origin

• Mutant Cell Line: OST284921
• Germline Transmission: Earliest citation of germline transmission: J:94077
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The Vapb gene consists of 6 exons. Retroviral insertion disrupted the gene in the intron between coding exons 1 and 2 (NCBI accession NM_019806.3). RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vapb Mutation: 28 strains or lines available

Notes

This Lexicon Genetics gene trap mutation was generated in either Lex-1 or Lex-2 (129S5/SvEvBrd) parental ES cell line. The specific ES cell line in which this mutation was made is not specified.

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 3 reference(s)