Tg(tetO-MAP2K1)#Ahsa
Transgene Detail

Summary

• Symbol: Tg(tetO-MAP2K1)#Ahsa
• Name: transgene insertion, AH Sawalha
• MGI ID: MGI:5056483
• Synonyms: TRE2-MEK
• Transgene: Tg(tetO-MAP2K1)#Ahsa Location: unknown
• Alliance: Tg(tetO-MAP2K1)#Ahsa page

Transgene origin

• Strain of Origin: C57BL/6 x (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: A dominant-negative mutation of a human cDNA encoding S218A, S222A, and K97A amino acid residue substitutions was placed under the control of TRE2 (tetO) regulatory elements. The purified construct was then injected into nuclei of one-celled embryos. (J:174339, J:174340)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:174339 Sawalha AH, et al., Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. Genes Immun. 2008 Jun;9(4):368-78
• All: 2 reference(s)