Ttbk2^tm1Dral
Targeted Allele Detail

Summary

• Symbol: Ttbk2^tm1Dral
• Name: tau tubulin kinase 2; targeted mutation 1, Dario R Alessi
• MGI ID: MGI:5056320
• Synonyms: TTBK2^fmly1, Ttbk2^sca11
• Gene: Ttbk2 Location: Chr2:120563297-120681085 bp, - strand Genetic Position: Chr2, 60.37 cM, cytoband F1
• Alliance: Ttbk2^tm1Dral page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173629
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Dominant negative)
• Mutation: Insertion
• Mutation details: An adenosine was inserted in exon 13. This mutation is observed in spinocerebellar ataxia type 11 family 1. (J:173629)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ttbk2 Mutation: 63 strains or lines available

References

• Original: J:173629 Bouskila M, et al., TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. Biochem J. 2011 Jul 1;437(1):157-67
• All: 2 reference(s)