Mrgprd^tm5Mjz
Targeted Allele Detail

Summary

• Symbol: Mrgprd^tm5Mjz
• Name: MAS-related GPR, member D; targeted mutation 5, Mark J Zylka
• MGI ID: MGI:5050632
• Synonyms: Mrgprd delta^PLAP
• Gene: Mrgprd Location: Chr7:144868572-144877796 bp, + strand Genetic Position: Chr7, 89.06 cM
• Alliance: Mrgprd^tm5Mjz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94938
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: In-frame knock in of human placental alkaline phosphatase (PLAP) fused to IRES-rtTA(M2). The entire ORF was deleted. PLAP is expressed in place of the ORF. (J:94938)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mrgprd Mutation: 24 strains or lines available

References

• Original: J:94938 Zylka MJ, et al., Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd. Neuron. 2005 Jan 6;45(1):17-25
• All: 3 reference(s)