Tg(tetO-Fasl)DDepa
Transgene Detail

Summary

• Symbol: Tg(tetO-Fasl)DDepa
• Name: transgene insertion D, Monique De Paepe
• MGI ID: MGI:5050408
• Transgene: Tg(tetO-Fasl)DDepa Location: unknown
• Alliance: Tg(tetO-Fasl)DDepa page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The (tetO)7-FasL transgene was designed with a Tet response element (TRE) upstream of the 943 bp murine Fas ligand (FasL) coding sequence, all followed by a bovine growth hormone intron and polyA sequence. The Tet response element (TRE) contains seven copies of the 42-bp tet operator sequence (tetO) just upstream of a minimal CMV promoter. Five founder lines (A-E) were established. Founder mice from line D were found with 20 copies of the transgene and intermediate levels of doxycycline-induced FasL mRNA up-regulation. (J:137382)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:137382 De Paepe ME, et al., Fas-ligand-induced apoptosis of respiratory epithelial cells causes disruption of postcanalicular alveolar development. Am J Pathol. 2008 Jul;173(1):42-56
• All: 1 reference(s)