Rr14^tm1.1Bulg
Targeted Allele Detail

Summary

• Symbol: Rr14^tm1.1Bulg
• Name: regulatory region 14; targeted mutation 1.1, Michael Bulger
• MGI ID: MGI:5049943
• Synonyms: HS-E1 deletion
• Gene: Rr14 Location: Chr7:103496069-103496784 bp Genetic Position: Chr7, Syntenic
• Alliance: Rr14^tm1.1Bulg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173283
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: Homologous recombination replaced a segment of genomic DNA located between Hbb-bh0 and Hbb-bh1 with a loxP site flanked neomycin resistance gene cassette. The segment of DNA replaced extended from 7500 bp downstream of the epsilon y-globin transcription start site to 8231 bp downstream (731 bp). The selectable marker was subsequently removed by crossing to Tg(CMV-cre)1Cgn transgenic mice. (J:173283)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr14 Mutation: 0 strains or lines available

References

• Original: J:173283 Fromm G, et al., An embryonic stage-specific enhancer within the murine beta-globin locus mediates domain-wide histone hyperacetylation. Blood. 2011 May 12;117(19):5207-14
• All: 1 reference(s)