Tg(CMV-CASP3)14Edge
Transgene Detail
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Symbol: |
Tg(CMV-CASP3)14Edge |
Name: |
transgene insertion 14, Albert Edge |
MGI ID: |
MGI:5014207 |
Synonyms: |
Mos-iCsp3 |
Transgene: |
Tg(CMV-CASP3)14Edge Location: unknown
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Alliance: |
Tg(CMV-CASP3)14Edge page
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Transgene Type: |
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Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Tg(CMV-CASP3)14Edge expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
CASP3 (836) |
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Mutation details: The Mos-iCsp3 transgene was designed with (from 5' to 3') a CMV promoter, a loxH site, a beta-galactosidase (lacZ) gene, a V5-tag (derived from the paramyxovirus of simian virus 5 (SV5)), a 6x-histidine-tag, a polyadenylation (polyA) signal, and a loxP. This floxed-lacZ-STOP cassette was followed by a myristoylation sequence, two tandem FK506-binding sites (Fvs), a human Caspase 3 (CASP3) gene, a haemagglutinin (HA) tag, and a second (polyA) signal. Lines 14 and 17 were generated.
(J:173515)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:173515 Fujioka M, et al., Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation. J Clin Invest. 2011 Jun 1;121(6):2462-9 |
All: |
2 reference(s) |
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