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Targeted Allele Detail
Symbol: L1td1tm1Yam
Name: LINE-1 type transposase domain containing 1; targeted mutation 1, Shinya Yamanaka
MGI ID: MGI:5008637
Synonyms: ECAT11EGFP
Gene: L1td1  Location: Chr4:98614991-98626723 bp, + strand  Genetic Position: Chr4, 45.6 cM
Alliance: L1td1tm1Yam page
Germline Transmission:  Earliest citation of germline transmission: J:172565
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe coding region was replaced with EGFP, IRES, and a puro cassette. The absence of protein expression was confirmed by western blot analysis on ES cell extracts. (J:172565)
Generation of the L1td1tm1Yam allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any L1td1 Mutation:  78 strains or lines available
Original:  J:172565 Iwabuchi KA, et al., ECAT11/L1td1 Is Enriched in ESCs and Rapidly Activated During iPSCGeneration, but It Is Dispensable for the Maintenance and Induction of Pluripotency. PLoS One. 2011;6(5):e20461
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory