Kdr^orv
Chemically induced Allele Detail

Summary

• Symbol: Kdr^orv
• Name: kinase insert domain protein receptor; orvieto
• MGI ID: MGI:5004965
• Synonyms: Flk-1^-
• Gene: Kdr Location: Chr5:76093487-76139118 bp, - strand Genetic Position: Chr5, 40.23 cM
• Alliance: Kdr^orv page

Absence of blood cells and vasculature in E9.5-10.5 Kdr^orv/Kdr^orv embryos

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: 129S1/Sv or C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: This phenotypic mutant was generated in an ENU mutagenesis screen for early craniofacial development phenotypes. The molecular mutation is a C-to-A mutation at bp 1311 of the coding sequence, which results in translation change of TYR to STOP. (J:243205)

Expression

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdr Mutation: 71 strains or lines available

References

• Original: J:171522 Sandell LL, et al., A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development. Genesis. 2011 Apr;49(4):342-59
• All: 2 reference(s)