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Gja1tm6.2(Gjb3)Kwi
Targeted Allele Detail
Summary
Symbol: Gja1tm6.2(Gjb3)Kwi
Name: gap junction protein, alpha 1; targeted mutation 6.2, Klaus Willecke
MGI ID: MGI:5004864
Synonyms: Cx43KICx43floxCx31
Gene: Gja1  Location: Chr10:56253297-56266519 bp, + strand  Genetic Position: Chr10, 28.64 cM
Alliance: Gja1tm6.2(Gjb3)Kwi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:82809
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites flank the coding region of Gja1. A single frt site remains immediately 3' of the polyadenylation signal as the result of FLP deletion of a frt-flanked neomycin resistance cassette from Gja1tm6(Gjb3)Kwi. The coding region and 88 bp of downstream sequence from Gja3 have been inserted between the Gja1 termination codon and its downstream DNA so that Cre recombinase mediated recombination will delete the Gja1 coding sequence and place that of Gja3 under control of the Gja1 regulatory sequences. (J:106509)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gja1 Mutation:  60 strains or lines available
References
Original:  J:106509 Zheng-Fischhofer Q, et al., Connexin31 cannot functionally replace connexin43 during cardiac morphogenesis in mice. J Cell Sci. 2006 Feb 15;119(Pt 4):693-701
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory