Fstl1^tm1.1Ning
Targeted Allele Detail

Summary

• Symbol: Fstl1^tm1.1Ning
• Name: follistatin-like 1; targeted mutation 1.1, Wen Ning
• MGI ID: MGI:4950852
• Gene: Fstl1 Location: Chr16:37597417-37656878 bp, + strand Genetic Position: Chr16, 26.48 cM
• Alliance: Fstl1^tm1.1Ning page

Fstl1^tm1.1Ning/Fstl1^tm1.1Ning neonates are cyanotic

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171347
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae x C57BL/6J

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 2 was floxed. Cre-mediated recombination removed exon 2. The absence of protein expression was confirmed by western blot analysis on E15.5 whole embryo and lung extracts. (J:171347)

Generation of the Fstl1^tm1.1Ning allele

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fstl1 Mutation: 44 strains or lines available

References

• Original: J:171347 Geng Y, et al., Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7058-63
• All: 8 reference(s)