Dazap1^tm1.1Pyen
Targeted Allele Detail

Summary

• Symbol: Dazap1^tm1.1Pyen
• Name: DAZ associated protein 1; targeted mutation 1.1, Pauline Yen
• MGI ID: MGI:4950678
• Synonyms: Dazap1^f, Dazap^tm115.36FYen
• Gene: Dazap1 Location: Chr10:80097320-80124242 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Dazap1^tm1.1Pyen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171493
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: One loxP site was inserted just upstrean of exon 2 and a floxed neomycin selection cassette in reverse orientation was inserted in intron 4. The floxed selection cassette was subsequently subjected to cre mediated excision leaving exons 2-4 which encode the first RNA binding domain flanked by loxP sites. Normal levels of unmodified protein are expressed. (J:171493)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dazap1 Mutation: 40 strains or lines available

References

• Original: J:171493 Hsu LC, et al., DAZAP1, an hnRNP protein, is required for normal growth and spermatogenesis in mice. RNA. 2008 Sep;14(9):1814-22
• All: 1 reference(s)