Slc25a25^tm1.1Kz
Targeted Allele Detail

Summary

• Symbol: Slc25a25^tm1.1Kz
• Name: solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25; targeted mutation 1.1, Leslie P Kozak
• MGI ID: MGI:4948968
• Gene: Slc25a25 Location: Chr2:32304499-32341457 bp, - strand Genetic Position: Chr2, 22.09 cM
• Alliance: Slc25a25^tm1.1Kz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170924
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette. The absence of transcript expression was confirmed by qRT-PCR analysis of liver, quadriceps, and inguinal fat extracts. (J:170924)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc25a25 Mutation: 40 strains or lines available

References

• Original: J:170924 Anunciado-Koza RP, et al., Inactivation of the Mitochondrial Carrier SLC25A25 (ATP-Mg2+/Pi Transporter) Reduces Physical Endurance and Metabolic Efficiency in Mice. J Biol Chem. 2011 Apr 1;286(13):11659-71
• All: 1 reference(s)