Myh14^tm2Rsad
Targeted Allele Detail

Summary

• Symbol: Myh14^tm2Rsad
• Name: myosin, heavy polypeptide 14; targeted mutation 2, Robert S Adelstein
• MGI ID: MGI:4948885
• Synonyms: 2CR722C
• Gene: Myh14 Location: Chr7:44255227-44320267 bp, - strand Genetic Position: Chr7, 28.85 cM, cytoband B2
• Alliance: Myh14^tm2Rsad page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171110
• Parent Cell Line: CMT-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Single point mutation
• Mutation details: The targeting vector was designed to change arginine to cysteine at amino acid position 722 (R722C) by substituting CGC for TGC in exon 17. A loxP-flanked pGK neomycin cassette was also inserted in the intron. Cre mediated recombination removed the neo cassette. (J:171110)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myh14 Mutation: 81 strains or lines available

References

• Original: J:171110 Adelstein RS, Generation of a Myh14 knockin with an R722C substitution. MGI Direct Data Submission. 2011
• All: 1 reference(s)