Kmt2c^tm1.2Jwle
Targeted Allele Detail

Summary

• Symbol: Kmt2c^tm1.2Jwle
• Name: lysine (K)-specific methyltransferase 2C; targeted mutation 1.2, Jae Lee
• MGI ID: MGI:4947973
• Synonyms: Mll3^f
• Gene: Kmt2c Location: Chr5:25476796-25703781 bp, - strand Genetic Position: Chr5, 12.35 cM
• Alliance: Kmt2c^tm1.2Jwle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170958
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 56 and an FRT site flanked neomycin resistance gene cassette followed by a second loxP site was inserted into intron 58. Sequence encoding 61 of the 121 amino acids of the SET domain were thus enclosed within loxP sites. The neo cassette was removed through subsequent Flp-mediated recombination, leaving exons 57-58, including sequence encoding the RYINHS motif of the catalytic core region of the SET domain, flanked by loxP sites. (J:116064)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2c Mutation: 181 strains or lines available

References

• Original: J:170958 Lee J, The frt-flanked neo cassette has been removed from Mll3^tm1.2Jwle. MGI Direct Data Submission. 2011
• All: 5 reference(s)