En1^tm1(Tnf)Fpit
Targeted Allele Detail

Summary

• Symbol: En1^tm1(Tnf)Fpit
• Name: engrailed 1; targeted mutation 1, F Pitossi
• MGI ID: MGI:4947582
• Synonyms: k-in
• Gene: En1 Location: Chr1:120530246-120535719 bp, + strand Genetic Position: Chr1, 52.74 cM, cytoband C2-qter
• Alliance: En1^tm1(Tnf)Fpit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170743
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The murine cDNA and floxed neo cassette was inserted the endogenous En1 promoter and coding region. The promoter drives expression in the substantia nigra and pons expression in adults. (J:170743)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any En1 Mutation: 32 strains or lines available

References

• Original: J:170743 Chertoff M, et al., Neuroprotective and neurodegenerative effects of the chronic expression of tumor necrosis factor alpha in the nigrostriatal dopaminergic circuit of adult mice. Exp Neurol. 2011 Feb;227(2):237-51
• All: 1 reference(s)