Derl2^tm1.1Hpl
Targeted Allele Detail

Summary

• Symbol: Derl2^tm1.1Hpl
• Name: Der1-like domain family, member 2; targeted mutation 1.1, Hidde Ploegh
• MGI ID: MGI:4947125
• Gene: Derl2 Location: Chr11:70898266-70910667 bp, - strand Genetic Position: Chr11, 43.21 cM
• Alliance: Derl2^tm1.1Hpl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:170650
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette. (J:170650)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Derl2 Mutation: 18 strains or lines available

References

• Original: J:170650 Dougan SK, et al., Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Mol Cell Biol. 2011 Mar;31(6):1145-59
• All: 4 reference(s)