Tg(tetO-tTA,-Rag1,-Rag2)1Dgs
Transgene Detail

Summary

• Symbol: Tg(tetO-tTA,-Rag1,-Rag2)1Dgs
• Name: transgene insertion 1, David G Schatz
• MGI ID: MGI:4943523
• Synonyms: Tg(tetO-tTA, tetO-Rag1, tetO-Rag2)1Dgs
• Transgene: Tg(tetO-tTA,-Rag1,-Rag2)1Dgs Location: unknown
• Alliance: Tg(tetO-tTA,-Rag1,-Rag2)1Dgs page

Transgene origin

• Strain of Origin: C57BL/6 x C3H

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Transactivator)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: Three transgenes were cointegrated and inherited en block. The transgenes contain the tTA (tet transactivator), RAG-1, and RAG-2 genes each driven by the autoregulatory tet system promoter, ie. the minimal CMV promoter and 7 copies of the tet operator. (J:87913)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:87913 Shockett PE, et al., Partial reconstitution of V(D)J rearrangement and lymphocyte development in RAG-deficient mice expressing inducible, tetracycline-regulated RAG transgenes. Mol Immunol. 2004 Jan;40(11):813-29
• All: 1 reference(s)