Adora2b^tm1Msit
Targeted Allele Detail

Summary

• Symbol: Adora2b^tm1Msit
• Name: adenosine A2b receptor; targeted mutation 1, Michail Sitkovsky
• MGI ID: MGI:4941885
• Gene: Adora2b Location: Chr11:62139810-62157278 bp, + strand Genetic Position: Chr11, 37.96 cM, cytoband B2
• Alliance: Adora2b^tm1Msit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169155
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. (J:169155)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adora2b Mutation: 19 strains or lines available

References

• Original: J:169155 Belikoff BG, et al., A2B adenosine receptor blockade enhances macrophage-mediated bacterial phagocytosis and improves polymicrobial sepsis survival in mice. J Immunol. 2011 Feb 15;186(4):2444-53
• All: 13 reference(s)