Plekha2^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Plekha2^tm1.1Arte
• Name: pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 2; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:4941747
• Synonyms: TAPP2^R218L, TAPP2R218L
• Gene: Plekha2 Location: Chr8:25529160-25592392 bp, - strand Genetic Position: Chr8, 13.7 cM
• Alliance: Plekha2^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:169475
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 8 was replaced with a loxP site, a modified exon 8 with nucleotide substitutions that result in the amino acid substitution of leucine for arginine at position 218 (R218L), and an FRT-flanked neo cassette with a 3' loxP site. Cre-mediated recombination removed the neo cassette leaving the modified exon 8 floxed. (J:169475)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plekha2 Mutation: 35 strains or lines available

References

• Original: J:169475 Wullschleger S, et al., Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis. Biochem J. 2011 Mar 1;434(2):265-74
• All: 4 reference(s)